Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities

The great diversity of marine habitats and organisms renders them a high-value source to find/develop novel drugs formulations. Therefore, herein, sardine (Sardina pilchardus) roe was used as lipidic produce liposomes. This fish product presents high nutritional value, being its content associated with important health benefits. Consequently, it can be advantageously therapeutically active delivery devices. Roe lipids were extracted using the Matyash method. After lipid film hydration extrusion, roe-derived large unilamellar liposomes (LUVs), designated fishroesomes, presented size ≈330 nm significant negative surface charge (≈−27 mV). Radical scavenging assays demonstrated that fishroesomes efficiently neutralized peroxyl, hydroxyl nitric oxide radicals. Moreover, significantly reduced expression pro-inflammatory cytokines chemokines by LPS-stimulated macrophages at non-toxic concentrations for L929 THP-1 cells. developed exhibit unique properties bioactive drug carriers inflammatory diseases treatment.